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Phospho-GSK3β-Y216 + GSK3α-Y279 Rabbit Polyclonal Antibody (CABP0512)

SKU:
CABP0512
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
$503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-GSK3β-Y216 + GSK3α-Y279 Rabbit Polyclonal Antibody
SKU:CABP0512
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around Y216 of human GSK3β (NP_001139628).
Sequence:VSYI C
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:GSK3B; gsk-3β; Phospho-GSK3β-Y216 + GSK3α-Y279
Positive Sample:293
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm, Nucleus.
Calculated MW:47kDa
Observed MW:50kDa

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification Method:Affinity purification
Gene ID:2931/2932
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of 293T cells, using Phospho-GSK3β-Y216 + GSK3α-Y279 antibody (CABP0512) at 1:1000 dilution. 293T cells were treated by Insulin (100nM) for 10 minutes or treated by 10% FBS for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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