The Rhodopsin Kinase Polyclonal Antibody (CAB2966) is an essential tool for research involving rhodopsin kinase, a critical enzyme in the visual cycle. Rhodopsin kinase plays a key role in the phosphorylation of rhodopsin, a light-sensitive receptor protein in the retina, which is essential for the adaptation of the eye to varying light conditions.Raised in rabbits, this antibody is highly specific and reactive with human samples, making it an ideal choice for immunohistochemistry and Western blot applications. By binding to rhodopsin kinase, this antibody enables the detection and analysis of this crucial enzyme in various cell types, providing valuable insights into the mechanisms underlying vision and potential therapeutic targets for retinal diseases.
The role of rhodopsin kinase in visual signaling makes it a key player in the maintenance of photoreceptor function and visual acuity. Dysregulation of rhodopsin kinase has been linked to various retinal degenerative diseases, highlighting the importance of studying this enzyme in the development of novel treatments for conditions such as retinitis pigmentosa and age-related macular degeneration.Overall, the Rhodopsin Kinase Polyclonal Antibody (CAB2966) is a valuable tool for researchers investigating the visual cycle and retinal diseases, offering high specificity and sensitivity for the detection of rhodopsin kinase in human samples. Its applications extend to studies in ophthalmology, vision research, and drug
Product Name:
GRK1 Rabbit Polyclonal Antibody
SKU:
CAB2966
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human GRK1 (NP_002920.1).
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2).
Purification Method:
Affinity purification
Gene ID:
6011
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using GRK1 Rabbit pAb (CAB2966) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
