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Phospho-GRIN2A/GRIN2B (Y1246/1252) Antibody (PACO03977)

SKU:
PACO03977
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
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Description

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Phospho-GRIN2A/GRIN2B (Y1246/1252) Antibody (PACO03977)

The Phospho-GRIN2A/GRIN2B (Y1246/1252) Antibody (PACO03977) is a valuable tool for researchers studying the phosphorylation of N-methyl-D-aspartate (NMDA) receptor subunits GRIN2A and GRIN2B. This polyclonal antibody, raised in rabbits, is highly specific and reacts with phosphorylated tyrosine residues 1246 and 1252 on these subunits. It has been validated for use in Western blot applications and can effectively detect and analyze the phosphorylation status of GRIN2A/GRIN2B in human samples.The phosphorylation of GRIN2A and GRIN2B plays a crucial role in the regulation of NMDA receptor activity, which is involved in synaptic plasticity, learning, and memory.

By targeting specific phosphorylation sites, researchers can gain insights into the mechanisms underlying neurological disorders such as Alzheimer's disease, schizophrenia, and epilepsy. This antibody is essential for investigating the signaling pathways and functional implications of phosphorylated GRIN2A and GRIN2B, making it a valuable tool for neuroscience and drug discovery research.

Antibody Name:Phospho-GRIN2A/GRIN2B (Y1246/1252) Antibody
Antibody SKU:PACO03977
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC, IF
Recommended Dilutions:IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human NMDAepsilon1/2 around the phosphorylation site of Y1246/1252.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:GRIN2A; NMDAR2A; Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A; GRIN2B; NMDAR2B; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; NMDAR2B; N
UniProt Protein Function:NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function:protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity

Biological Process: startle response; positive regulation of apoptosis; regulation of synaptic plasticity; sensory perception of pain; dopamine metabolic process; synaptic transmission; protein localization; learning and/or memory; transport; response to wounding; visual learning; serotonin metabolic process; response to drug; synaptic transmission, glutamatergic; glutamate signaling pathway; response to amphetamine; sleep; memory; response to ethanol; neurogenesis; ionotropic glutamate receptor signaling pathway; directional locomotion; regulation of sensory perception of pain; regulation of excitatory postsynaptic membrane potential; negative regulation of protein catabolic process

Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation

NCBI Summary:This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
UniProt Code:Q12879
NCBI GenInfo Identifier:14285603
NCBI Gene ID:2903
NCBI Accession:Q12879.1
UniProt Secondary Accession:Q12879,O00669, Q17RZ6,
UniProt Related Accession:Q12879
Molecular Weight:144,431 Da
NCBI Full Name:Glutamate receptor ionotropic, NMDA 2A
NCBI Synonym Full Names:glutamate receptor, ionotropic, N-methyl D-aspartate 2A
NCBI Official Symbol:GRIN2A  
NCBI Official Synonym Symbols:LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A  
NCBI Protein Information:glutamate receptor ionotropic, NMDA 2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor subunit 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1
UniProt Protein Name:Glutamate receptor ionotropic, NMDA 2A
UniProt Synonym Protein Names:Glutamate [NMDA] receptor subunit epsilon-1; N-methyl D-aspartate receptor subtype 2A; NMDAR2A; NR2A; hNR2A
Protein Family:Glutamate receptor ionotropic
UniProt Gene Name:GRIN2A  
UniProt Entry Name:NMDE1_HUMAN

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