The Phospho-GRIN1 (S896) Polyclonal Antibody (CABP0165) is designed for research involving GRIN1, a subunit of the NMDA receptor involved in synaptic plasticity and memory formation. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications including Western blot, immunohistochemistry, and immunofluorescence.GRIN1, specifically phosphorylated at Serine 896, plays a crucial role in regulating NMDA receptor activity and synaptic transmission. Dysregulation of this phosphorylation site has been implicated in various neurological disorders such as Alzheimer's disease, epilepsy, and schizophrenia.
Understanding the dynamics of Phospho-GRIN1 (S896) is essential for unraveling the molecular mechanisms underlying these conditions and developing targeted therapies.This antibody binds specifically to the phosphorylated form of GRIN1 at Serine 896, allowing for precise detection and analysis of this critical signaling pathway in neurons and other cell types. Its high specificity and sensitivity make it an invaluable tool for researchers studying the complex interplay between NMDA receptor function and neurological disorders.
Product Name:
Phospho-NMDAR1-S896 Rabbit Polyclonal Antibody
SKU:
CABP0165
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around S896 of human NMDAR1 (NP_015566.1).
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
2902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse Brain tissue, using Phospho-NMDAR1-S896 Rabbit pAb (CABP0165).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
