The Phospho-GRIN1 (S890) Polyclonal Antibody (CABP0826) is an essential tool for researchers studying the function of GRIN1, a key component of the NMDA receptor complex in the brain. This antibody is specifically designed to detect phosphorylated GRIN1 at serine 890, a critical site for regulating the activity of the receptor in synaptic plasticity and memory formation.Raised in rabbits, this antibody exhibits high specificity and sensitivity for detecting phosphorylated GRIN1 in human samples, making it an invaluable tool for Western blot applications. By targeting the phosphorylated form of GRIN1, researchers can investigate the role of this receptor in neurological disorders, including Alzheimer's disease, schizophrenia, and epilepsy.
The Phospho-GRIN1 (S890) Polyclonal Antibody (CABP0826) enables precise detection and analysis of GRIN1 phosphorylation in various cell types and tissues, providing insights into the mechanisms underlying synaptic transmission and neuronal signaling. Its use in neuroscience research holds promise for uncovering new therapeutic targets and strategies for treating cognitive and neurological disorders.
Product Name:
Phospho-NMDAR1-S890 Rabbit Polyclonal Antibody
SKU:
CABP0826
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
A synthetic phosphorylated peptide around S890 of human NMDAR1 (NP_015566.1).
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
2902
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from C6 cells, using Phospho-NMDAR1-S890 Rabbit pAb (CABP0826) at 1:1000 dilution. C6 cells were treated by PMA/TPA (200nM) for 30 minutes after serum-starvation overnight.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
