The Phospho-GRIA2 (S880) Polyclonal Antibody (CABP0257) is a valuable tool for researchers studying the phospho-modification of the Glutamate Ionotropic Receptor AMPA Type Subunit 2 (GRIA2) protein. This antibody, generated in rabbits, specifically detects the phosphorylation of serine 880 on the GRIA2 protein in human samples, making it ideal for use in Western blot applications.Phosphorylation of the GRIA2 protein at serine 880 is known to modulate the function of AMPA receptors in the central nervous system, influencing synaptic plasticity and neurotransmission. Therefore, studying this phosphorylation event is crucial for understanding processes like learning and memory, as well as neurological disorders.
The Phospho-GRIA2 (S880) Polyclonal Antibody enables precise detection and quantification of phosphorylated GRIA2 protein, allowing researchers to investigate the role of this post-translational modification in various cell types and experimental conditions. This antibody is a valuable tool for neuroscience research, offering insights into the mechanisms underlying synaptic transmission and potential targets for therapeutic intervention in neurological disorders.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.
Purification Method:
Affinity purification
Gene ID:
2891
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain tissue using Phospho-GluR2/GRIA2-S880 Rabbit pAb (CABP0257) and the same antibody preincubated with blocking peptide.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
