The Phospho-GRIA1 (S836) Polyclonal Antibody (CABP0356) is designed for research involving the phosphorylation of the GRIA1 protein, a key player in synaptic transmission and plasticity in the brain. This antibody, raised in rabbits, is highly specific and sensitive to phosphorylation at the S836 site on GRIA1, making it ideal for Western blot analysis in human samples.GRIA1, also known as GluA1, is a subunit of the AMPA receptor, which is essential for excitatory neurotransmission in the central nervous system. Phosphorylation of GRIA1 at the S836 site is known to regulate the trafficking and functional properties of AMPA receptors, impacting synaptic strength and plasticity.
Understanding the phosphorylation status of GRIA1 is crucial for investigating mechanisms of synaptic transmission and the pathophysiology of neurological disorders such as Alzheimer's disease and epilepsy.By using the Phospho-GRIA1 (S836) Polyclonal Antibody, researchers can accurately detect and quantify the phosphorylated form of GRIA1 in various cell types and tissues, providing valuable insights into the role of GRIA1 phosphorylation in synaptic function and dysfunction. This antibody is a valuable tool for studies in neuroscience, neurobiology, and drug development targeting AMPA receptors.
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2890
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain, using Phospho-GluR1/GRIA1-S836 Rabbit pAb (CABP0356).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
