The Gab2 Polyclonal Antibody (CAB13066) is a powerful tool for researchers studying Gab2, a protein involved in cell signaling pathways and cancer development. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards Gab2 in human samples, making it ideal for Western blotting and immunohistochemistry experiments.Gab2, a member of the Gab/DOS family of scaffolding proteins, is known to play a key role in various cellular processes such as cell growth, survival, and migration. Dysregulation of Gab2 expression and activity has been linked to the progression of several types of cancer, making it an attractive target for therapeutic intervention.
By using the Gab2 Polyclonal Antibody, researchers can accurately detect and analyze Gab2 protein levels in different cell types and tissues, providing valuable insights into its functions and potential as a therapeutic target. This antibody is a valuable tool for investigations in cancer biology, signal transduction, and drug discovery aimed at targeting Gab2-mediated pathways for novel anti-cancer strategies.
Product Name:
GAB2 Rabbit Polyclonal Antibody
SKU:
CAB13066
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 377-676 of human GAB2 (NP_536739.1).
This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
9846
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using GAB2 Rabbit pAb (CAB13066) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.
