The FOSB Polyclonal Antibody (CAB14696) is a valuable tool for researchers investigating the FOSB protein, a transcription factor involved in various cellular processes such as cell proliferation, differentiation, and transformation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the FOSB protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cancer research and developmental biology.FOSB, a member of the Fos family of transcription factors, plays a crucial role in regulating gene expression in response to a variety of stimuli, including growth factors and stress signals.
Its involvement in several signaling pathways makes it a key player in the control of cell growth and differentiation. Understanding the function of FOSB is essential for unraveling its role in physiological processes and disease states, particularly in cancer where dysregulation of FOSB expression is frequently observed. By using the FOSB Polyclonal Antibody, researchers can gain valuable insights into the molecular mechanisms underlying FOSB-mediated functions, paving the way for potential therapeutic strategies targeting this important transcription factor.
Product Name:
FOSB Rabbit Polyclonal Antibody
SKU:
CAB14696
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FOSB (NP_006723.2).
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
2354
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using FOSB Rabbit pAb (CAB14696) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
