Phospho-FLT3-Y589/591 Rabbit Polyclonal Antibody (CABP0529)
- SKU:
- CABP0529
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Frequently bought together:
Description
Product Name: | Phospho-FLT3-Y589/591 Rabbit Polyclonal Antibody |
SKU: | CABP0529 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around Y589 & Y591 of human FLT3 (NP_004110.2). |
Sequence: | EYFY V |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:100 - 1:500 |
Synonyms: | FLK2; STK1; CD135; FLK-2; Phospho-FLT3-Y589/591 |
Positive Sample: | A-431 |
Conjugate: | Unconjugated |
Cellular Localization: | Endoplasmic reticulum lumen, Membrane, Single-pass type I membrane protein. |
Calculated MW: | 113kDa |
Observed MW: | 160kDa |
This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Purification Method: | Affinity purification |
Gene ID: | 2322 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |