The FLT1 Polyclonal Antibody (CAB0058) is a valuable tool for research involving the FLT1 protein, also known as VEGFR-1. This cell surface receptor is a key player in angiogenesis, the process of forming new blood vessels from existing ones. The antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.FLT1 is essential for blood vessel development and maintenance, making it a crucial target for studies in vascular biology and diseases such as cancer, cardiovascular disorders, and retinopathy. By detecting and analyzing FLT1 protein expression in various cell types, researchers can gain insight into its role in promoting or inhibiting angiogenesis, and its potential as a therapeutic target in disease treatment.
Understanding the function of FLT1 is vital for developing new strategies to modulate angiogenesis and target blood vessel formation in pathological conditions. The FLT1 Polyclonal Antibody offers researchers a reliable tool for investigating the role of this protein in both normal and disease states, advancing our knowledge of vascular biology and potential treatment options.
Product Name:
VEGFR1 Rabbit Polyclonal Antibody
SKU:
CAB0058
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1180 of human VEGFR1 (NP_002010.2).
Cell membrane, Cytoplasm, Endosome, Secreted, Single-pass type I membrane protein.
Calculated MW:
151kDa
Observed MW:
200kDa
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Purification Method:
Affinity purification
Gene ID:
2321
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using VEGFR1 Rabbit pAb (CAB0058) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
