FHIT Rabbit Polyclonal Antibody (CAB1196)
- SKU:
- CAB1196
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | FHIT Rabbit Polyclonal Antibody |
SKU: | CAB1196 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-147 of human FHIT (NP_001159715.1). |
Sequence: | LVNR KPVV PGHV LVCP LRPV ERFH DLRP DEVA DLFQ TTQR VGTV VEKH FHGT SLTF SMQD GPEA GQTV KHVH VHVL PRKA GDFH RNDS IYEE LQKH DKED FPAS WRSE EEMA AEAA ALRV YFQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | FRA3B; AP3Aase; FHIT |
Positive Sample: | A-549,HeLa,Jurkat,293T,Mouse liver,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Mitochondrion, Nucleus. |
Calculated MW: | 17kDa |
Observed MW: | 17kDa |
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage.
Purification Method: | Affinity purification |
Gene ID: | 2272 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |