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Phospho-FGFR1/FGFR2 (Y463/466) Antibody (PACO02717)

SKU:
PACO02717
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-FGFR1/FGFR2 (Y463/466) Antibody (PACO02717)

Based on the information provided in the URL, the Phospho-FGFR1/FGFR2 (Y463/466) Antibody (PAC02717) is a valuable tool for researchers studying the phosphorylation of FGFR1 and FGFR2 proteins. This antibody is designed to specifically target the phosphorylated tyrosine residues at positions 463 and 466 on these receptors, which are key for their activation and downstream signaling pathways.The Phospho-FGFR1/FGFR2 (Y463/466) Antibody is produced using high-quality rabbit polyclonal antibodies, ensuring high reactivity with human samples. It has been validated for use in Western blot applications, allowing for the detection and analysis of phosphorylated FGFR1 and FGFR2 proteins in various cell types.

The FGFR1 and FGFR2 receptors play essential roles in cell growth, differentiation, and survival, making them relevant targets for research in cancer and other diseases. By targeting the phosphorylated tyrosine residues on these receptors, researchers can better understand the mechanisms by which they activate signaling cascades and contribute to cellular responses.Overall, the Phospho-FGFR1/FGFR2 (Y463/466) Antibody (PAC02717) is a valuable tool for scientists studying the phosphorylation of FGFR1 and FGFR2 proteins, providing insights into their roles in cellular signaling and potential implications for disease development and treatment strategies.

Antibody Name:Phospho-FGFR1/FGFR2 (Y463/466) Antibody
Antibody SKU:PACO02717
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Flg/Bek around the phosphorylation site of Y463/466.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR; Fibroblast growth factor receptor 1; FGFR-1; Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr; CD antigen CD331; FGFR2; BE
UniProt Protein Function:FGFR1: a receptor tyrosine kinase of the highly-conserved fibroblast growth factor receptor (FGFR). Binds both acidic and basic fibroblast growth factors and is involved in limb induction. Point mutations cause Pfeffer syndrome (finger and toe malformations and other skeletal errors) and dominant Kallmann syndrome 2. Stem cell leukemia lymphoma syndrome (SCLL) may be caused by a t(8;13)(p12;q12) translocation that fuses a zinc finger gene, ZNF198, to FGFR1. Various myeloproliferative disorders have been linked to translocations that fuse FGFR1 to FOP, FIM, CEP1 or the atypical kinase, Bcr. Inhibitor: SU5402. 20 isoforms of the human protein produced by alternative splicing have been described.
UniProt Protein Details:

Protein type:Protein kinase, TK; Protein kinase, tyrosine (receptor); Oncoprotein; EC 2.7.10.1; Membrane protein, integral; Kinase, protein; TK group; FGFR family

Chromosomal Location of Human Ortholog: 8p11.23-p11.22

Cellular Component: integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; plasma membrane; integral to membrane; nucleus; cytosol; receptor complex

Molecular Function:heparin binding; identical protein binding; protein binding; fibroblast growth factor binding; protein homodimerization activity; fibroblast growth factor receptor activity; protein-tyrosine kinase activity; ATP binding

Biological Process: paraxial mesoderm development; axon guidance; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; protein amino acid autophosphorylation; cell maturation; neuron migration; negative regulation of transcription from RNA polymerase II promoter; middle ear morphogenesis; protein amino acid phosphorylation; positive regulation of MAP kinase activity; sensory perception of sound; positive regulation of MAPKKK cascade; ureteric bud development; regulation of cell differentiation; induction of an organ; midbrain development; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; chondrocyte differentiation; angiogenesis; skeletal development; embryonic limb morphogenesis; positive regulation of cardiac muscle cell proliferation; epidermal growth factor receptor signaling pathway; inner ear morphogenesis; cell migration; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; chordate embryonic development; transcription, DNA-dependent; in utero embryonic development; outer ear morphogenesis; MAPKKK cascade; positive regulation of cell cycle; neuroblast division in the ventricular zone; positive regulation of phosphoinositide 3-kinase cascade; mesenchymal cell differentiation; skeletal morphogenesis; insulin receptor signaling pathway; auditory receptor cell development; innate immune response; positive regulation of neuron differentiation; regulation of lateral mesodermal cell fate specification

Disease: Pfeiffer Syndrome; Hypogonadotropic Hypogonadism 2 With Or Without Anosmia; Jackson-weiss Syndrome; Trigonocephaly 1; Osteoglophonic Dysplasia

NCBI Summary:The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:P11362
NCBI GenInfo Identifier:120046
NCBI Gene ID:2260
NCBI Accession:P11362.3
UniProt Secondary Accession:P11362,P17049, Q02063, Q02065, Q14306, Q14307, Q53H63 Q59H40, Q5BJG2, A8K6T9, A8K8V5, C1KBH8,
UniProt Related Accession:P11362
Molecular Weight:91,868 Da
NCBI Full Name:Fibroblast growth factor receptor 1
NCBI Synonym Full Names:fibroblast growth factor receptor 1
NCBI Official Symbol:FGFR1  
NCBI Official Synonym Symbols:CEK; FLG; HH2; OGD; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1  
NCBI Protein Information:fibroblast growth factor receptor 1; FGFR1/PLAG1 fusion; proto-oncogene c-Fgr; FMS-like tyrosine kinase 2; hydroxyaryl-protein kinase; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; basic fibroblast growth factor receptor 1
UniProt Protein Name:Fibroblast growth factor receptor 1
UniProt Synonym Protein Names:Basic fibroblast growth factor receptor 1; BFGFR; bFGF-R-1; Fms-like tyrosine kinase 2; FLT-2; N-sam; Proto-oncogene c-Fgr
UniProt Gene Name:FGFR1  
UniProt Entry Name:FGFR1_HUMAN

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