The Fanconi Anemia Complementation Group A (FANCA) Polyclonal Antibody (CAB7671) is a powerful tool for research involving Fanconi Anemia, a genetic disorder characterized by bone marrow failure and an increased risk of cancer. This antibody, generated in rabbits, is highly specific for human FANCA and has been validated for use in various applications, including Western blotting.FANCA is a key member of the Fanconi Anemia pathway, which is involved in DNA repair and the maintenance of genomic stability. Dysregulation of this pathway can lead to the development of Fanconi Anemia and an increased susceptibility to cancer.
The FANCA Polyclonal Antibody enables the detection and analysis of FANCA protein expression in cells, offering valuable insights into the role of this protein in DNA repair mechanisms and disease development.With its high specificity and reliability in detecting FANCA, this antibody is an invaluable tool for researchers studying Fanconi Anemia, cancer biology, and DNA repair pathways. By understanding the function of FANCA and its role in disease, novel therapeutic approaches may be developed to target Fanconi Anemia and related disorders.
Product Name:
FANCA Rabbit Polyclonal Antibody
SKU:
CAB7671
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-275 of human FANCA (NP_000126.2).
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group A. Alternative splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are the most common cause of Fanconi anemia.
Purification Method:
Affinity purification
Gene ID:
2175
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using FANCA antibody (CAB7671) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
