Phospho-FADD-S194 Rabbit Polyclonal Antibody (CABP1054)
- SKU:
- CABP1054
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | Phospho-FADD-S194 Rabbit Polyclonal Antibody |
SKU: | CABP1054 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around S194 of human FADD (NP_003815.1). |
Sequence: | AMSP M |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | GIG3; IMD90; MORT1; Phospho-FADD-S194 |
Positive Sample: | HeLa |
Cellular Localization: | cytoplasm, cytosol, neuron projection, nucleus, plasma membrane, ripoptosome |
Calculated MW: | 23kDa |
Observed MW: | 28kDa |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
Purification Method: | Affinity purification |
Gene ID: | 8772 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |