Anti-Phospho-EZR-Y353 Antibody (CABP1118)
- SKU:
- CABP1118
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-Phospho-EZR-Y353 Antibody (CABP1118)
The Phospho-EZR (Y353) Polyclonal Antibody (CABP1118) is a specialized tool for studying phosphorylation of the Ezrin Radixin Moesin (ERM) protein family member, Ezrin. This antibody specifically targets the Y353 phosphorylation site on Ezrin, a key regulator of cell shape and motility. Raised in rabbits, this antibody is highly sensitive and validated for use in various applications, including Western blot and immunohistochemistry.Phosphorylation of Ezrin at Y353 plays a crucial role in regulating its function in cell signaling, adhesion, and migration. By specifically detecting this phosphorylation site, researchers can gain valuable insights into the activation and downstream effects of Ezrin in various cellular processes.
This antibody is ideal for studies in cell biology, cancer research, and metastasis, where understanding Ezrin phosphorylation dynamics is essential for deciphering its role in disease progression.Overall, the Phospho-EZR (Y353) Polyclonal Antibody (CABP1118) offers researchers a reliable tool for investigating the phosphorylation status of Ezrin and its impact on cellular functions, paving the way for new discoveries in cell biology and therapeutic development.
| Antibody Name: | Anti-Phospho-EZR-Y353 Antibody |
| Antibody SKU: | CABP1118 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y353 of human EZR. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | 293T |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding Y353 of human EZR. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 7430 |
| Uniprot: | P15311 |
| Cellular Location: | Apical cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Peripheral membrane protein, cell cortex, cytoskeleton, microvillus membrane, ruffle membrane |
| Calculated MW: | 69kDa |
| Observed MW: | 70kDa |
 | Western blot - Phospho-EZR-Y353 Rabbit pAb (CABP1118) |
| Synonyms: | EZR, CVIL, CVL, HEL-S-105, VIL2, ezrin |
| Background: | The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | Ezrin: a member of the ERM family which includes radixin and moesin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons. Plays a key role in cell surface structure adhesion, migration, and organization. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytoskeletal Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: cortical cytoskeleton; extracellular space; microvillus; focal adhesion; basolateral plasma membrane; T-tubule; actin filament; cytosol; lipid raft; actin cytoskeleton; ruffle; extrinsic to membrane; membrane; apical part of cell; microvillus membrane; apical plasma membrane; nucleolus; plasma membrane; uropod; vesicle; filopodium Molecular Function:actin filament binding; protein domain specific binding; protein binding; cell adhesion molecule binding Biological Process: actin filament bundle formation; axon guidance; microvillus biogenesis; regulation of cell shape; leukocyte adhesion; filopodium formation; cytoskeletal anchoring; receptor internalization; membrane to membrane docking; establishment of epithelial cell polarity |
| NCBI Summary: | The cytoplasmic peripheral membrane protein encoded by this gene functions as a protein-tyrosine kinase substrate in microvilli. As a member of the ERM protein family, this protein serves as an intermediate between the plasma membrane and the actin cytoskeleton. This protein plays a key role in cell surface structure adhesion, migration and organization, and it has been implicated in various human cancers. A pseudogene located on chromosome 3 has been identified for this gene. Alternatively spliced variants have also been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P15311 |
| NCBI GenInfo Identifier: | 125987826 |
| NCBI Gene ID: | 7430 |
| NCBI Accession: | P15311.4 |
| UniProt Secondary Accession: | P15311,P23714, Q4VX75, Q96CU8, Q9NSJ4, E1P5A8, |
| UniProt Related Accession: | P15311 |
| Molecular Weight: | 586 |
| NCBI Full Name: | Ezrin |
| NCBI Synonym Full Names: | ezrin |
| NCBI Official Symbol: | EZRÂ Â |
| NCBI Official Synonym Symbols: | CVL; CVIL; VIL2; HEL-S-105Â Â |
| NCBI Protein Information: | ezrin; p81; villin-2; cytovillin 2; villin 2 (ezrin); epididymis secretory protein Li 105 |
| UniProt Protein Name: | Ezrin |
| UniProt Synonym Protein Names: | Cytovillin; Villin-2; p81 |
| Protein Family: | Ezrin |
| UniProt Gene Name: | EZRÂ Â |
| UniProt Entry Name: | EZRI_HUMAN |
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