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Phospho-ERF (T526) Antibody (PACO03638)

SKU:
PACO03638
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-ERF (T526) Antibody (PACO03638)

The Phospho-ERF (T526) Antibody (PAC003638) is a valuable tool for researchers studying the ERF protein, a transcription factor involved in regulating gene expression. This antibody, generated in rabbits, is highly specific to phosphorylated ERF at threonine 526 and is validated for use in various applications, including Western blotting. By targeting the phosphorylated form of ERF, this antibody enables the detection and analysis of ERF activation in different cell types, making it ideal for studying signaling pathways and cellular responses in both normal and disease conditions.ERF, also known as ETS domain-containing transcription factor, plays a key role in controlling gene expression in response to various stimuli, including growth factors and environmental stress.

Phosphorylation of ERF at threonine 526 has been linked to its activation and involvement in cellular processes such as proliferation, differentiation, and apoptosis. Understanding the regulation of ERF activity, particularly its phosphorylation status, is essential for unraveling its biological functions and exploring its potential as a therapeutic target in diseases like cancer and developmental disorders.

Antibody Name:Phospho-ERF (T526) Antibody
Antibody SKU:PACO03638
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human ERF around the phosphorylation site of T526.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ERF; ETS domain-containing transcription factor ERF; Ets2 repressor factor; PE-2
UniProt Protein Function:ERF: potent transcriptional repressor that binds to the H1 element of the ETS2 promoter. Belongs to the ETS family of transcription factors. Its function is regulated by phosphorylation.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: cytosol; Golgi apparatus; nucleoplasm; nucleus

Molecular Function:sequence-specific DNA binding; transcription corepressor activity

Biological Process: cell cycle; cell differentiation; negative regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Craniosynostosis 4

NCBI Summary:ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
UniProt Code:P50548
NCBI GenInfo Identifier:50403684
NCBI Gene ID:2077
NCBI Accession:P50548.2
UniProt Secondary Accession:P50548,Q59G38, Q9UPI7, B2RAP1, B7Z4R0,
UniProt Related Accession:P50548
Molecular Weight:49,965 Da
NCBI Full Name:ETS domain-containing transcription factor ERF
NCBI Synonym Full Names:ETS2 repressor factor
NCBI Official Symbol:ERF  
NCBI Official Synonym Symbols:PE2; CRS4; PE-2  
NCBI Protein Information:ETS domain-containing transcription factor ERF
UniProt Protein Name:ETS domain-containing transcription factor ERF
UniProt Synonym Protein Names:Ets2 repressor factor; PE-2
Protein Family:Essential recombination function protein
UniProt Gene Name:ERF  
UniProt Entry Name:ERF_HUMAN

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