Phospho-ErbB4/HER4-Y1284 Rabbit Polyclonal Antibody (CABP0034)
- SKU:
- CABP0034
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Description
Product Name: | Phospho-ErbB4/HER4-Y1284 Rabbit Polyclonal Antibody |
SKU: | CABP0034 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around Y1284 of human ErbB4/HER4 (NP_005226.1). |
Sequence: | PEYL S |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | HER4; ALS19; p180erbB4; Phospho-ErbB4/HER4-Y1284 |
Positive Sample: | MCF7+IGF |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Mitochondrion, Nucleus, Single-pass type I membrane protein. |
Calculated MW: | 147kDa |
Observed MW: | 180kDa |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Purification Method: | Affinity purification |
Gene ID: | 2066 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |