The EPS15 Polyclonal Antibody (CAB9814) is a valuable tool for researchers studying the EPS15 protein, a key player in clathrin-mediated endocytosis and intracellular signaling pathways. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards EPS15 in human samples, making it ideal for Western blot applications.EPS15 is involved in regulating the internalization of cell surface receptors and the formation of clathrin-coated pits, essential processes for cell signaling and homeostasis. Dysregulation of EPS15 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting its importance in cellular function.
By targeting EPS15, researchers can gain insights into the mechanisms governing endocytosis and signaling cascades, paving the way for the development of novel therapeutic strategies. The EPS15 Polyclonal Antibody offers a reliable tool for investigating the role of EPS15 in different cellular contexts, making it a valuable asset for studies in cell biology and disease research.
Product Name:
EPS15 Rabbit Polyclonal Antibody
SKU:
CAB9814
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 660-840 of human EPS15 (NP_001972.1).
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Purification Method:
Affinity purification
Gene ID:
2060
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using EPS15 antibody (CAB9814) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 15s.
