The Anti-Epha3/Epha4/Epha5 Antibody (CAB20254) is a versatile tool for researchers studying the Eph receptor family, specifically EphA3, EphA4, and EphA5. These cell surface receptors play important roles in cell signaling and are involved in processes such as cell migration, adhesion, and axon guidance. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blotting applications. It binds specifically to the Epha3, Epha4, and Epha5 proteins, allowing for the detection and analysis of these receptors in various cell types.
The Eph receptors, including EphA3, EphA4, and EphA5, are known to be dysregulated in a variety of diseases, including cancer, neurological disorders, and cardiovascular diseases. Research into these receptors and their signaling pathways is vital for understanding diseases at the molecular level and developing targeted therapies. The Anti-Epha3/Epha4/Epha5 Antibody (CAB20254) is a valuable tool for researchers investigating the functions of these receptors and their potential as therapeutic targets.
Product Name:
EPHA3/EPHA4/EPHA5 Polyclonal Antibody
SKU:
CAB20254
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 700-800 of human EPHA3/EPHA4/EPHA5 (NP_005224.2).
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Purification Method:
Affinity purification
Gene ID:
2042/2043/2044
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded rat kidney using EPHA3/EPHA4/EPHA5 pAb (CAB20254) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
