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Phospho-EPHA2/EPHA5 (Y594) Antibody (PACO02631)

SKU:
PACO02631
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-EPHA2/EPHA5 (Y594) Antibody (PACO02631)

The Phospho-EphA2 (EphA5 Y594) Antibody (PACO02631) is a valuable tool for researchers studying the EphA2 and EphA5 proteins, key regulators of cellular signaling pathways involved in cell growth, migration, and adhesion. This polyclonal antibody, raised in rabbits, is highly specific to the phosphorylated form of EphA2 at tyrosine 594 and is validated for use in various applications, including Western blot and immunohistochemistry.EphA2 and EphA5 are members of the Eph receptor tyrosine kinase family, known for their roles in cell-cell communication and tissue development. The phosphorylation of EphA2 at tyrosine 594 is a critical event in the activation of downstream signaling cascades that control cellular processes such as proliferation and differentiation.

By targeting this specific phosphorylation site, researchers can gain insights into the function of EphA2 and EphA5 in normal physiology and disease states, particularly in cancer and neurological disorders.With its high reactivity and specificity, the Phospho-EphA2 (EphA5 Y594) Antibody (PACO02631) is an essential tool for investigating the signaling pathways mediated by EphA2 and EphA5, providing valuable information for understanding their roles in health and disease.

Antibody Name:Phospho-EPHA2/EPHA5 (Y594) Antibody
Antibody SKU:PACO02631
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human EphA2/5 around the phosphorylation site of Y594.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EPHA2; ECK; Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA5; BSK; EHK1; HEK7; TYRO4; Ephrin type-A receptor 5; Brain-specific kinase; EPH homology kinase 1; EHK-1; EPH-like kinase 7; EK7; hEK7
UniProt Protein Function:EphA2: a receptor tyrosine kinase. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A3, -A4 AND -A5. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels. Overexpressed in many cancers including aggressive ovarian, cervical and breast carcinomas, and lung cancer. Expression correlates with degree of angiogenesis, metastasis and xenograft tumor growth. Soluble receptor inhibits tumor growth and angiogenesis in mice.
UniProt Protein Details:

Protein type:Protein kinase, TK; Membrane protein, integral; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; TK group; Eph family

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cell surface; focal adhesion; integral to plasma membrane; intracellular; plasma membrane

Molecular Function:ATP binding; ephrin receptor activity; protein binding; transmembrane receptor protein tyrosine kinase activity

Biological Process: angiogenesis; axial mesoderm formation; axon guidance; bone remodeling; cell adhesion; cell migration; DNA damage response, signal transduction resulting in induction of apoptosis; ephrin receptor signaling pathway; keratinocyte differentiation; mammary gland epithelial cell proliferation; multicellular organismal development; negative regulation of protein kinase B signaling cascade; neural tube development; notochord cell development; notochord formation; osteoblast differentiation; osteoclast differentiation; peptidyl-tyrosine phosphorylation; protein kinase B signaling cascade; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of cell adhesion mediated by integrin; skeletal development; vasculogenesis; viral reproduction

Disease: Cataract 6, Multiple Types

NCBI Summary:This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.[provided by RefSeq, May 2010]
UniProt Code:P29317
NCBI GenInfo Identifier:229462861
NCBI Gene ID:1969
NCBI Accession:P29317.2
UniProt Secondary Accession:P29317,Q8N3Z2, B5A968,
UniProt Related Accession:P29317
Molecular Weight:
NCBI Full Name:Ephrin type-A receptor 2
NCBI Synonym Full Names:EPH receptor A2
NCBI Official Symbol:EPHA2  
NCBI Official Synonym Symbols:ECK; CTPA; ARCC2; CTPP1; CTRCT6  
NCBI Protein Information:ephrin type-A receptor 2
UniProt Protein Name:Ephrin type-A receptor 2
UniProt Synonym Protein Names:Epithelial cell kinase; Tyrosine-protein kinase receptor ECK
Protein Family:Ephrin type-A receptor
UniProt Gene Name:EPHA2  
UniProt Entry Name:EPHA2_HUMAN

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