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Phospho-ELK3 (S357) Antibody (PACO02640)

SKU:
PACO02640
Product Type:
Antibody
Reactivity:
Human
Mouse
NHP - Monkey
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-ELK3 (S357) Antibody (PACO02640)

The Phospho-Elk3 (S357) Antibody (PACO02640) is a valuable tool for researchers studying Elk3, a transcription factor involved in cell proliferation and differentiation. This antibody, raised in rabbits, specifically targets the phosphorylated form of Elk3 at Serine 357, allowing for precise detection and analysis in Western blot applications.Elk3 plays a crucial role in various cellular processes, including cell cycle regulation and apoptosis, making it a key player in cancer research. The phosphorylation of Elk3 at Serine 357 is known to impact its activity, and this antibody provides researchers with a means to study and understand this important post-translational modification.

With its high reactivity with human samples and validated performance in Western blot assays, the Phospho-Elk3 (S357) Antibody is an essential tool for investigating Elk3 function in cancer biology and beyond. Its potential applications in cell signaling studies and drug development make it a valuable asset for researchers seeking to unravel the complexities of Elk3 signaling pathways.

Antibody Name:Phospho-ELK3 (S357) Antibody
Antibody SKU:PACO02640
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC, IF
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000
Species Reactivity:Human, Mouse, Monkey
Immunogen:synthesized peptide derived from human Net around the phosphorylation site of S357.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ELK3; NET; SAP2; ETS domain-containing protein Elk-3; ETS-related protein ERP; ETS-related protein NET; Serum response factor accessory protein 2; SAP-2; SRF accessory protein 2
UniProt Protein Function:ELK3: a transcription factor of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. May be a negative regulator of transcription but can activate transcription when co expressed with Ras, Src or Mos. Activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.
UniProt Protein Details:

Protein type:DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 12q23

Cellular Component: intracellular membrane-bound organelle; mitochondrion; nucleoplasm; nucleus

Molecular Function:protein binding; purine-rich negative regulatory element binding; transcription corepressor activity

Biological Process: cell differentiation; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction

NCBI Summary:This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Code:P41970
NCBI GenInfo Identifier:116241349
NCBI Gene ID:2004
NCBI Accession:P41970.2
UniProt Secondary Accession:P41970,Q6FG57, Q6GU29, Q9UD17, B2R6S6,
UniProt Related Accession:P41970,AAB34628
Molecular Weight:44,240 Da
NCBI Full Name:ETS domain-containing protein Elk-3
NCBI Synonym Full Names:ELK3, ETS transcription factor
NCBI Official Symbol:ELK3  
NCBI Official Synonym Symbols:ERP; NET; SAP2; SAP-2  
NCBI Protein Information:ETS domain-containing protein Elk-3
UniProt Protein Name:ETS domain-containing protein Elk-3
UniProt Synonym Protein Names:ETS-related protein ERP; ETS-related protein NET; Serum response factor accessory protein 2; SAP-2; SRF accessory protein 2
Protein Family:ETS domain-containing protein
UniProt Gene Name:ELK3  
UniProt Entry Name:ELK3_HUMAN

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