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Phospho-eIF4EBP1-T36 Rabbit Polyclonal Antibody (CABP0344)

SKU:
CABP0344
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
€419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-eIF4EBP1-T36 Rabbit Polyclonal Antibody
SKU:CABP0344
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:A synthetic phosphorylated peptide around T36 of human eIF4EBP1 (NP_004086.1).
Sequence:YSTT P
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:BP-1; 4EBP1; 4E-BP1; PHAS-I; Phospho-eIF4EBP1-T36
Positive Sample:MDA-MB-435
Conjugate:Unconjugated
Cellular Localization:cytoplasm, cytosol
Calculated MW:13kDa
Observed MW:20kDa

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Purification Method:Affinity purification
Gene ID:1978
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from MDA-MB-435 cells, using Phospho-eIF4EBP1-T36 Rabbit pAb (CABP0344).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.

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