The Phospho-EGFR (Y998) Polyclonal Antibody (CABP0024) is a valuable tool for researchers studying the activity of the epidermal growth factor receptor (EGFR) in various cellular processes. EGFR is a key signaling molecule involved in cell growth, proliferation, and differentiation, with phosphorylation at tyrosine 998 playing a critical role in its activation.This antibody, generated in rabbits, is highly specific for detecting phosphorylated EGFR at tyrosine 998 in human samples. It is validated for use in Western blot applications, allowing for precise detection and quantification of phosphorylated EGFR for further analysis.
The phosphorylation status of EGFR is known to influence its downstream signaling pathways, affecting cell survival, proliferation, and migration. Research into the role of EGFR phosphorylation in cancer, particularly in tumor progression and response to therapy, is of great interest in the field of oncology.By utilizing the Phospho-EGFR (Y998) Polyclonal Antibody, researchers can gain valuable insights into the regulation of EGFR signaling and its implications in disease, ultimately leading to the development of targeted therapies for EGFR-driven cancers and other related conditions.
Product Name:
Phospho-EGFR-Y998 Rabbit Polyclonal Antibody
SKU:
CABP0024
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around Y998 of human EGFR (NP_005219.2).
Cell membrane, Endoplasmic reticulum membrane, Endosome, Endosome membrane, Golgi apparatus membrane, Nucleus membrane, Nucleus, Secreted, Single-pass type I membrane protein.
Calculated MW:
134kDa
Observed MW:
200kDa
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Purification Method:
Affinity purification
Gene ID:
1956
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
