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Phospho-EFNB1/EFNB2 (Y329) Antibody (PACO03584)

SKU:
PACO03584
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-EFNB1/EFNB2 (Y329) Antibody (PACO03584)

The Phospho-EFNB1/EFNB2 (Y329) Antibody (PAC03584) is a valuable tool for researchers studying the phosphorylation of the EFNB1 and EFNB2 proteins, key players in the Eph/ephrin signaling pathway. This antibody, produced in rabbits, is highly specific for detecting phosphorylation at the tyrosine 329 site of EFNB1 and EFNB2 in human samples, making it ideal for use in Western blot applications.The Eph/ephrin signaling pathway is involved in a wide range of cellular processes, including cell adhesion, migration, and axon guidance. The phosphorylation of EFNB1 and EFNB2 at tyrosine 329 is important for regulating the activity of these proteins and ultimately impacting downstream signaling events.

By using the Phospho-EFNB1/EFNB2 (Y329) Antibody, researchers can gain insight into the role of EFNB1 and EFNB2 phosphorylation in various cell types and explore its implications in development, cancer, and neurological disorders.Understanding the phosphorylation status of EFNB1 and EFNB2 is essential for unraveling the complexities of the Eph/ephrin signaling pathway and its involvement in disease. The Phospho-EFNB1/EFNB2 (Y329) Antibody provides a reliable tool for investigating these crucial phosphorylation events and advancing research in signal transduction and cell biology.

Antibody Name:Phospho-EFNB1/EFNB2 (Y329) Antibody
Antibody SKU:PACO03584
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Ephrin-B1/2 around the phosphorylation site of Y329.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EFNB1; EFL3; EPLG2; LERK2; Ephrin-B1; EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2; EFNB2; EPLG5; HTKL; LERK5; Ephrin-B2; EPH-related receptor tyrosine kinase ligand 5; LERK-5; HTK ligand; HTK-L
UniProt Protein Function:EFNB1: a type I membrane protein of the ephrin family. A ligand of Eph-related receptor tyrosine kinases EphB1 and EphA1. Ephrins and ephrin receptors mediate numerous developmental processes, particularly in the nervous system. Ephrin-B1 may play a role in cell adhesion and functions in the development or maintenance of the nervous system. Binding to its receptor induces the collapse of commissural axons/growth cones in vitro. Induced by TNF-alpha. Expressed in brain, heart, placenta, lung, liver, skeletal muscle, kidney, and pancreas.
UniProt Protein Details:

Protein type:Membrane protein, integral; Ligand, receptor tyrosine kinase

Chromosomal Location of Human Ortholog: Xq12

Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; synapse; nucleus; lipid raft

Molecular Function:protein binding; ephrin receptor binding

Biological Process: axon guidance; cell-cell signaling; ephrin receptor signaling pathway; positive regulation of T cell proliferation; cell adhesion; embryonic pattern specification; neural crest cell migration

Disease: Craniofrontonasal Syndrome

NCBI Summary:The protein encoded by this gene is a type I membrane protein and a ligand of Eph-related receptor tyrosine kinases. It may play a role in cell adhesion and function in the development or maintenance of the nervous system. [provided by RefSeq, Jul 2008]
UniProt Code:P98172
NCBI GenInfo Identifier:1706668
NCBI Gene ID:1947
NCBI Accession:P98172.1
UniProt Secondary Accession:P98172,D3DVU0,
UniProt Related Accession:P98172
Molecular Weight:346
NCBI Full Name:Ephrin-B1
NCBI Synonym Full Names:ephrin-B1
NCBI Official Symbol:EFNB1  
NCBI Official Synonym Symbols:CFND; CFNS; EFB1; EFL3; EPLG2; Elk-L; LERK2  
NCBI Protein Information:ephrin-B1; EFL-3; LERK-2; ELK ligand; ligand of eph-related kinase 2; eph-related receptor tyrosine kinase ligand 2
UniProt Protein Name:Ephrin-B1
UniProt Synonym Protein Names:EFL-3; ELK ligand; ELK-L; EPH-related receptor tyrosine kinase ligand 2; LERK-2
Protein Family:Ephrin
UniProt Gene Name:EFNB1  
UniProt Entry Name:EFNB1_HUMAN

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