The DNM1L Polyclonal Antibody (CAB0650) is a valuable tool for researchers studying DNM1L, a protein involved in mitochondrial dynamics and fission. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the DNM1L protein, this antibody enables researchers to detect and analyze DNM1L expression in various cell types, making it ideal for investigations in cell biology and neurodegenerative diseases.
DNM1L, also known as dynamin-1-like protein, plays a crucial role in mitochondrial fission, a process essential for mitochondrial quality control and cellular homeostasis. Dysregulation of DNM1L has been implicated in various neurodegenerative disorders, making it a promising target for therapeutic intervention. By studying the function of DNM1L, researchers can gain insights into mitochondrial dynamics and potentially develop new treatments for neurological diseases.
Product Name:
DRP1 Rabbit Polyclonal Antibody
SKU:
CAB0650
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 610-736 of human DRP1 (NP_036192.2).
This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10059
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using DRP1 Rabbit pAb (CAB0650) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
