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Phospho-DMTN (S403) Antibody (PACO03624)

SKU:
PACO03624
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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Phospho-DMTN (S403) Antibody (PACO03624)

The Phospho-DMTN (S403) Antibody (PACO03624) is a valuable tool for researchers studying the phosphorylation of DMTN, a protein involved in cellular processes. This polyclonal antibody, derived from rabbit hosts, is highly specific to human samples and has been validated for use in Western blot applications. By binding to the phosphorylated form of DMTN at Serine 403, this antibody allows for the detection and analysis of this important protein modification in various cell types.DMTN, also known as dematin, is a cytoskeletal protein that plays a role in cell shape and movement. Phosphorylation of DMTN at Serine 403 may regulate its function, impacting cellular processes such as adhesion and migration.

Research on phosphorylation events like this one is essential for understanding cell signaling pathways and their implications in physiological and pathological conditions.The Phospho-DMTN (S403) Antibody is a valuable tool for investigating the role of DMTN phosphorylation in various cellular processes, making it ideal for studies in cell biology, signal transduction, and disease mechanisms. By elucidating the function of phosphorylated DMTN, researchers can gain insights into potential therapeutic targets for diseases where abnormal cell signaling and cytoskeletal dynamics contribute to pathology.

Antibody Name:Phospho-DMTN (S403) Antibody
Antibody SKU:PACO03624
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse
Immunogen:synthesized peptide derived from human Dematin around the phosphorylation site of S403.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:EPB49; DMT; Dematin; Erythrocyte membrane protein band 4.9
UniProt Protein Function:dematin: a probable DNA binding protein, with a Myb-like DNA-binding and ELM2 domain.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; Tumor suppressor; Actin-binding

Chromosomal Location of Human Ortholog: 8p21.1

Cellular Component: actin cytoskeleton; actin filament; cell projection membrane; cortical cytoskeleton; cytoplasmic membrane-bound vesicle; cytosol; endomembrane system; perinuclear region of cytoplasm; plasma membrane

Molecular Function:actin binding; protein binding; protein self-association; receptor binding; spectrin binding

Biological Process: actin cytoskeleton organization and biogenesis; actin filament bundle formation; actin filament capping; cytoskeleton organization and biogenesis; erythrocyte development; negative regulation of focal adhesion formation; negative regulation of peptidyl-serine phosphorylation; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of blood coagulation; protein complex assembly; regulation of actin cytoskeleton organization and biogenesis; regulation of cell shape; regulation of filopodium formation; transmembrane transport

NCBI Summary:The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2014]
UniProt Code:Q08495
NCBI GenInfo Identifier:22654240
NCBI Gene ID:2039
NCBI Accession:Q08495.3
UniProt Secondary Accession:Q08495,Q13215, Q9BRE3, A8K0T5, B3KP70, B3KRH3, B4DI75 E9PEJ0,
UniProt Related Accession:Q08495
Molecular Weight:41,558 Da
NCBI Full Name:Dematin
NCBI Synonym Full Names:dematin actin binding protein
NCBI Official Symbol:DMTN  
NCBI Official Synonym Symbols:DMT; EPB49  
NCBI Protein Information:dematin
UniProt Protein Name:Dematin
UniProt Synonym Protein Names:Dematin actin-binding protein; Erythrocyte membrane protein band 4.9
Protein Family:Dematin
UniProt Gene Name:DMTN  
UniProt Entry Name:DEMA_HUMAN

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