The Phospho-DDR1 (Y792) Rabbit Polyclonal Antibody (CABP1072) is a powerful tool for research involving the DDR1 protein, specifically phosphorylated at tyrosine 792. DDR1 is a receptor tyrosine kinase that plays a crucial role in cell adhesion, migration, and proliferation, making it a key player in cancer progression and metastasis.This antibody, raised in rabbits, shows high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the phosphorylated form of DDR1 at tyrosine 792, researchers can accurately detect and analyze DDR1 activation in various cell types, providing valuable insights into its role in cancer biology.
Understanding the phosphorylation status of DDR1 at tyrosine 792 is essential for elucidating its signaling pathways and potential therapeutic targets in cancer. By using this antibody, researchers can further explore the mechanisms by which DDR1 drives tumorigenesis and metastasis, paving the way for the development of targeted therapies for cancer treatment.
Product Name:
Phospho-DDR1-Y792 Rabbit Polyclonal Antibody
SKU:
CABP1072
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around Y792 of human DDR1 (NP_054699.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
101kDa
Observed MW:
125kDa
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
780
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using Phospho-DDR1-Y792 Rabbit pAb (CABP1072) at 1:1000 dilution. 293T cells were treated by ATP(5 mM) at 30℃ for 1 hour. NIH/3T3 cells were treated by ATP(5 mM) at 30℃ for 1 hour. C6 cells were treated by ATP(5 mM) at 30℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
