The DDR1 Polyclonal Antibody (CAB10487) is specifically designed for research involving DDR1, a receptor tyrosine kinase that plays a crucial role in cell adhesion and migration. The antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. It targets the DDR1 protein, allowing for detection and analysis in various cell types, making it an excellent tool for studies in cancer research and cell signaling pathways.DDR1, also known as discoidin domain receptor 1, is involved in various cellular processes such as cell proliferation, differentiation, and survival. Dysregulation of DDR1 has been linked to cancer progression, highlighting its importance as a potential therapeutic target in cancer treatment.
Research into DDR1 can provide valuable insights into the underlying mechanisms of cancer development and identify novel therapeutic strategies for targeting this receptor in cancer therapy.Overall, the DDR1 Polyclonal Antibody (CAB10487) is a valuable tool for researchers aiming to investigate the role of DDR1 in cancer biology and other related fields. Its high specificity and sensitivity make it an ideal choice for Western blot experiments to study DDR1 expression levels and cellular signaling pathways involved in cancer progression.
Product Name:
DDR1 Rabbit Polyclonal Antibody
SKU:
CAB10487
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 290-420 of human DDR1 (NP_054700.2).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
101kDa
Observed MW:
125kDa
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
780
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using DDR1 antibody (CAB10487) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
