Phospho-Cyclin D1-T286 Rabbit Polyclonal Antibody (CABP1061)
- SKU:
- CABP1061
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Description
Product Name: | Phospho-Cyclin D1-T286 Rabbit Polyclonal Antibody |
SKU: | CABP1061 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around T286 of human Cyclin D1 (NP_444284.1). |
Sequence: | ACTP T |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | BCL1; PRAD1; U21B31; D11S287E; Phospho-Cyclin D1-T286 |
Positive Sample: | NIH/3T3 |
Cellular Localization: | Cytoplasm, Membrane, Nucleus. |
Calculated MW: | 34kDa |
Observed MW: | 37kDa |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers.
Purification Method: | Affinity purification |
Gene ID: | 595 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |