null

Phospho-CSNK1A1/CSNK1A1L (Y294) Antibody (PACO02492)

SKU:
PACO02492
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Phospho-CSNK1A1/CSNK1A1L (Y294) Antibody (PACO02492)

The Phospho-CSNK1A1/CSNK1A1L (Y294) Antibody (PACO02492) is a valuable tool for researchers studying the phosphorylation of CSNK1A1 and CSNK1A1L proteins. This polyclonal antibody, produced in rabbits, is highly specific for the phosphorylated form of CSNK1A1/CSNK1A1L at the Y294 site and shows strong reactivity with human samples.This antibody is validated for use in Western blot applications, allowing for the detection and analysis of phosphorylated CSNK1A1/CSNK1A1L in various cell types. The phosphorylation of CSNK1A1 and CSNK1A1L plays a role in various cellular processes, including cell cycle regulation, signal transduction, and gene expression, making this antibody an essential tool for studies in cell biology and cancer research.

By targeting the phosphorylated form of CSNK1A1/CSNK1A1L at the Y294 site, researchers can gain valuable insights into the signaling pathways and regulatory mechanisms involving these proteins. Understanding the role of phosphorylation in the activity of CSNK1A1 and CSNK1A1L is crucial for advancing our knowledge of cell signaling and developing targeted therapies for diseases related to dysregulated phosphorylation events.

Antibody Name:Phospho-CSNK1A1/CSNK1A1L (Y294) Antibody
Antibody SKU:PACO02492
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:Human, Mouse, Rat
Immunogen:synthesized peptide derived from human Casein Kinase Ialpha around the phosphorylation site of Y294.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CSNK1A1; Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1L; Casein kinase I isoform alpha-like; CKI-alpha-like; CK1
UniProt Protein Function:CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation.
UniProt Protein Details:

Protein type:Protein kinase, CK1; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; CK1 family

Chromosomal Location of Human Ortholog: 5q32

Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck

Molecular Function:kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; Wnt receptor signaling pathway

UniProt Code:P48729
NCBI GenInfo Identifier:31077177
NCBI Gene ID:1452
NCBI Accession:P48729.2
UniProt Secondary Accession:P48729,Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2 Q9UDK3, D3DQG0, D3DQG1,
UniProt Related Accession:P48729
Molecular Weight:37,567 Da
NCBI Full Name:Casein kinase I isoform alpha
NCBI Synonym Full Names:casein kinase 1 alpha 1
NCBI Official Symbol:CSNK1A1  
NCBI Official Synonym Symbols:CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p  
NCBI Protein Information:casein kinase I isoform alpha
UniProt Protein Name:Casein kinase I isoform alpha
UniProt Synonym Protein Names:CK1
Protein Family:Casein kinase
UniProt Gene Name:CSNK1A1  
UniProt Entry Name:KC1A_HUMAN

Related Products