The Phospho-CREB1 (S133) Monoclonal Antibody is a valuable tool for researchers studying CREB1, a transcription factor involved in gene regulation and cellular signaling. This monoclonal antibody, produced using cutting-edge technology, is highly specific and sensitive in detecting phosphorylation of CREB1 at serine 133, a crucial post-translational modification that regulates its activity.CREB1 plays a vital role in various biological processes, including neuronal plasticity, memory formation, and cell survival. Phosphorylation at serine 133 is known to enhance CREB1's transcriptional activity and influence downstream gene expression. Therefore, the Phospho-CREB1 (S133) Monoclonal Antibody is an essential tool for elucidating the signaling pathways and mechanisms involved in these processes.
This antibody is suitable for Western blotting applications and has been validated for use in human samples, ensuring reliable and reproducible results. Its specificity and sensitivity make it an ideal choice for studies in neuroscience, cancer biology, and other fields where CREB1 signaling plays a significant role. Researchers can rely on this monoclonal antibody to accurately detect and analyze phosphorylated CREB1, advancing our understanding of its functions and potential therapeutic targets.
Product Name:
Phospho-CREB1-S133 Monoclonal Antibody
SKU:
CABP1421
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around Ser133 of human CREB1.
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P,1:50 - 1:200
Synonyms:
CREB; CREB-1; Phospho-CREB1-S133
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
35kDa
Observed MW:
Refer to figures
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1385
Clone Number:
ARC60280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma using Phospho-CREB1-S133 Rabbit mAb (CABP1421) at dilution of 1:100 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
