The Anti-CCR5 Antibody (CAB20261) is a key tool for researchers studying the CCR5 protein, a cell surface receptor involved in immune responses and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By targeting the CCR5 protein, this antibody allows for the detection and analysis of CCR5 in different cell types, making it an essential resource for studies in immunology, infectious diseases, and HIV/AIDS research.CCR5, a chemokine receptor, plays a crucial role in the migration and activation of immune cells, making it a significant target for therapeutic interventions in conditions such as HIV infection and inflammatory diseases.
By understanding the function and regulation of CCR5, researchers can develop novel treatments that target this receptor to modulate immune responses and control inflammatory processes. The Anti-CCR5 Antibody is a valuable tool for advancing research in these areas and uncovering new possibilities for disease intervention.
Product Name:
CCR5 Rabbit Polyclonal Antibody
SKU:
CAB20261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 246-345 of human CCR5 (NP_000570.1).
cell surface, cytoplasm, endosome, external side of plasma membrane, plasma membrane
Calculated MW:
41kDa
Observed MW:
41kDa
This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
1234
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat liver, using CCR5 antibody (CAB20261) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
