Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody (CABP1400)
- SKU:
- CABP1400
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
Product Name: | Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody |
SKU: | CABP1400 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around S23 & S24 of human Cardiac Troponin I (TNNI3) (NP_000354.4). |
Sequence: | RRSS NY |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:500 - 1:1000 |
Synonyms: | CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Phospho-Cardiac Troponin I (TNNI3)-S23/S24 |
Conjugate: | Unconjugated |
Cellular Localization: | cardiac myofibril, cytosol, sarcomere |
Calculated MW: | 24kDa |
Observed MW: | Refer to figures |
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
Purification Method: | Affinity purification |
Gene ID: | 7137 |
Clone Number: | ARC56024 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |