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Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody (CABP1400)

SKU:
CABP1400
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
IHC
€139 - €609
Frequently bought together:

Description

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Product Name:Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody
SKU:CABP1400
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around S23 & S24 of human Cardiac Troponin I (TNNI3) (NP_000354.4).
Sequence:RRSS NY
Tested Applications:IHC-P ELISA
Recommended Dilution:IHC-P,1:500 - 1:1000
Synonyms:CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Phospho-Cardiac Troponin I (TNNI3)-S23/S24
Conjugate:Unconjugated
Cellular Localization:cardiac myofibril, cytosol, sarcomere
Calculated MW:24kDa
Observed MW:Refer to figures

Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.

Purification Method:Affinity purification
Gene ID:7137
Clone Number:ARC56024
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Product ImageImmunohistochemistry analysis of paraffin-embedded Human heart using Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb (CABP1400) at dilution of 1:700 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

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