Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody (CABP1400)
The Phospho-Cardiac Troponin I (TNNI3 S23/S24) Monoclonal Antibody is a valuable tool for researchers investigating cardiac troponin I, a key protein involved in regulating cardiac muscle contraction. This antibody, developed for use in Western blot applications, specifically detects the phosphorylated form of cardiac troponin I at serine 23/24 residues.Phosphorylation of cardiac troponin I at these specific sites has been linked to various cardiac conditions, making this antibody essential for studying the molecular mechanisms underlying cardiac disease progression. Its high specificity for the phosphorylated form of troponin I in human samples ensures accurate and reliable results in research related to heart diseases, myocardial infarction, and other cardiovascular disorders.
With its ability to target and detect phosphorylated cardiac troponin I, the Phospho-Cardiac Troponin I (TNNI3 S23/S24) Monoclonal Antibody is an invaluable resource for researchers aiming to better understand the role of this protein in cardiac function and disease. Its application in studying cardiac biomarkers and potential therapeutic targets makes it a crucial tool for advancing cardiovascular research and developing novel treatment strategies for heart-related conditions.
Product Name:
Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Monoclonal Antibody
SKU:
CABP1400
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S23 & S24 of human Cardiac Troponin I (TNNI3) (NP_000354.4).
Sequence:
RRSS NY
Tested Applications:
IHC-PELISA
Recommended Dilution:
IHC-P,1:500 - 1:1000
Synonyms:
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; Phospho-Cardiac Troponin I (TNNI3)-S23/S24
Conjugate:
Unconjugated
Cellular Localization:
cardiac myofibril, cytosol, sarcomere
Calculated MW:
24kDa
Observed MW:
Refer to figures
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19.
Purification Method:
Affinity purification
Gene ID:
7137
Clone Number:
ARC56024
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human heart using Phospho-Cardiac Troponin I (TNNI3)-S23/S24 Rabbit mAb (CABP1400) at dilution of 1:700 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
