Phospho-CAMK2A/CAMK2B/CAMK2D (T305) Antibody (PACO06155)
- SKU:
- PACO06155
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Phospho-CAMK2A/CAMK2B/CAMK2D (T305) Antibody (PACO06155)
The Phospho-CaMK2A/CaMK2B/CaMK2D (T305) Antibody (PACO06155) is a highly specific and sensitive antibody designed for research involving calcium/calmodulin-dependent protein kinases (CaMK2) phosphorylated at threonine 305. This antibody, raised in rabbits, is validated for use in a variety of applications, including Western blot, immunoprecipitation, and immunofluorescence.CaMK2 proteins play essential roles in various cellular processes, including synaptic plasticity, gene expression, and cell survival. Phosphorylation at threonine 305 is a crucial regulatory mechanism that modulates the activity of CaMK2 isoforms A, B, and D.
The Phospho-CaMK2A/CaMK2B/CaMK2D (T305) Antibody specifically recognizes this phosphorylated form, allowing for precise detection and analysis in different experimental settings.With its high specificity and sensitivity, this antibody is a valuable tool for researchers studying CaMK2 signaling pathways in physiological and pathological contexts. Understanding the role of phosphorylated CaMK2 isoforms in cellular signaling can provide insights into diseases such as neurodegenerative disorders, cardiovascular diseases, and cancer, where dysregulation of CaMK2 activity has been implicated.
| Antibody Name: | Phospho-CAMK2A/CAMK2B/CAMK2D (T305) Antibody (PACO06155) |
| Antibody SKU: | PACO06155 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:5000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human CaMKII α / β / delta around the phosphorylation site of T305. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of 453 293T cells using Phospho-CaMKII alpha / beta / delta (T305) Polyclonal Antibody. |
 | Western Blot analysis of 453 cells using Phospho-CaMKIIalpha / beta / delta (T305) Polyclonal Antibody. |
| Synonyms: | CAMK2A; CAMKA; KIAA0968; Calcium/calmodulin-dependent protein kinase type II subunit α; CaM kinase II subunit α; CaMK-II subunit α; CAMK2B; CAM2; CAMK2; CAMKB; Calcium/calmodulin-dependent protein kinase type II subunit β; Ca |
| UniProt Protein Function: | CAMK2A: a protein kinase of the CAMK2 family. A prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses that may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity. The holoenzyme is composed of four different chains: alpha, beta, gamma, and delta. The different chains assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. May interact with BAALC, MPDZ, SYN1 and synGAP. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, CAMK; EC 2.7.11.17; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; CAMK2 family Chromosomal Location of Human Ortholog: 5q32 Cellular Component: cytosol; mitochondrion; nucleoplasm; nucleus; plasma membrane Molecular Function:calmodulin binding; glutamate receptor binding; kinase activity; protein binding; protein homodimerization activity; protein serine/threonine kinase activity; Ras guanyl-nucleotide exchange factor activity Biological Process: activation of NF-kappaB transcription factor; calcium ion transport; G1/S transition of mitotic cell cycle; MAPKKK cascade; peptidyl-serine phosphorylation; positive regulation of calcium ion transport; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of neuronal synaptic plasticity; regulation of neurotransmitter secretion; Wnt receptor signaling pathway, calcium modulating pathway |
| NCBI Summary: | The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9UQM7 |
| NCBI GenInfo Identifier: | 296434552 |
| NCBI Gene ID: | 815 |
| NCBI Accession: | Q9UQM7.2 |
| UniProt Secondary Accession: | Q9UQM7,Q9UL21, Q9Y2H4, Q9Y352, |
| UniProt Related Accession: | Q9UQM7 |
| Molecular Weight: | 55,320 Da |
| NCBI Full Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
| NCBI Synonym Full Names: | calcium/calmodulin dependent protein kinase II alpha |
| NCBI Official Symbol: | CAMK2AÂ Â |
| NCBI Official Synonym Symbols: | CAMKAÂ Â |
| NCBI Protein Information: | calcium/calmodulin-dependent protein kinase type II subunit alpha |
| UniProt Protein Name: | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
| Protein Family: | Calcium/calmodulin-dependent protein kinase |
| UniProt Gene Name: | CAMK2AÂ Â |
| UniProt Entry Name: | KCC2A_HUMAN |
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