null

Phospho-c-Myc-T58 Rabbit Monoclonal Antibody (CABP0990)

SKU:
CABP0990
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
€419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Phospho-c-Myc-T58 Rabbit Monoclonal Antibody
SKU:CABP0990
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:A synthetic phosphorylated peptide around T58 of human c-Myc (P01106).
Sequence:LPTP P
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:MRTL; MYCC; c-Myc; bHLHe39; Phospho-c-Myc-T58
Positive Sample:HeLa
Conjugate:Unconjugated
Cellular Localization:Nucleus, Nucleolus, Nucleoplasm.
Calculated MW:51kDa
Observed MW:57kDa

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

Purification Method:Affinity purification
Gene ID:4609
Clone Number:ARC1534
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of HeLa cells, using Phospho-c-Myc-T58 Rabbit mAb (CABP0990) at 1:1000 dilution.Hela cells were treated by CIP(20uL/400ul) at 37℃ for 1 hour.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

Related Products