The BTK Polyclonal Antibody (CAB12738) is a valuable tool for researchers studying Bruton's tyrosine kinase (BTK), a key enzyme involved in B-cell development and function. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the BTK protein, this antibody enables the detection and analysis of BTK expression in a variety of cell types, making it an essential component for studies in immunology, oncology, and autoimmune disorders.BTK plays a crucial role in B-cell receptor signaling and is implicated in the pathogenesis of B-cell malignancies such as leukemia and lymphoma.
Inhibitors targeting BTK have shown promise as therapeutic agents for these diseases, making the study of BTK expression and activity essential for the development of novel treatments. The BTK Polyclonal Antibody provides researchers with a reliable tool for investigating the role of BTK in health and disease, ultimately contributing to the advancement of precision medicine in cancer and immunological disorders.
Product Name:
BTK Rabbit Polyclonal Antibody
SKU:
CAB12738
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant Protein corresponding to a sequence within amino acids 173-272 of human BTK (NP_000052.1).
The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
695
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using BTK Rabbit pAb (CAB12738) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime: 1s.
