The Phospho-Beclin-1 (Ser93) Antibody (CABP1287) is a valuable tool for researchers studying the autophagy pathway and its role in cellular processes. This antibody, produced in rabbits, is highly specific and reacts strongly with human samples, making it an excellent choice for Western blot applications. By binding to the phosphorylated form of Beclin-1 at Serine 93, this antibody enables the detection and analysis of Beclin-1 in various cell types.Beclin-1 is a key regulator of autophagy, a cellular recycling process that plays a critical role in maintaining cellular homeostasis and responding to stress.
Phosphorylation of Beclin-1 at Serine 93 has been linked to its activation and regulation of autophagy, making it an important target for research in cancer, neurodegenerative diseases, and other conditions.Studying the phosphorylation status of Beclin-1 can provide valuable insights into the mechanisms underlying autophagy and its impact on cellular function. The Phospho-Beclin-1 (Ser93) Antibody (CABP1287) is a reliable tool for researchers seeking to explore the role of Beclin-1 in autophagy and its potential implications for human health and disease.
Product Name:
Phospho-Beclin 1-Ser93 Polyclonal Antibody
SKU:
CABP1287
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic phosphorylated peptide around S93 of human Beclin 1 (NP_003757.1).
This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
8678
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using Phospho-Beclin 1-Ser93 antibody (CABP1287) at 1:500 dilution.HeLa cells were treated by Calyculin A (100 nM) at 37℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
