Phospho-BCR-Y177 Rabbit Polyclonal Antibody (CABP0606)
- SKU:
- CABP0606
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | Phospho-BCR-Y177 Rabbit Polyclonal Antibody |
SKU: | CABP0606 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic phosphorylated peptide around Y177 of human BCR (NP_004318.3). |
Sequence: | PFYV N |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ALL; CML; PHL; BCR1; D22S11; D22S662; Phospho-BCR-Y177 |
Positive Sample: | K562 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, postsynaptic cell membrane, postsynaptic density, synapse. |
Calculated MW: | 143kDa |
Observed MW: | 160kDa |
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 613 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |