The Phospho-Bcl2 (T56) Polyclonal Antibody (CABP0316) is designed for research involving the phosphorylated form of the Bcl2 protein, which plays a crucial role in regulating apoptosis (cell death) in response to various stimuli. The antibody, produced in rabbits, is highly specific to the phosphorylation site Threonine 56 on the Bcl2 protein and is validated for use in Western blot applications. It allows for the detection and analysis of phosphorylated Bcl2 in different cell types, making it an ideal tool for studies in cell signaling pathways and cancer research.Phosphorylation of Bcl2 at Threonine 56 has been shown to modulate its anti-apoptotic function, influencing cell survival and resistance to programmed cell death.
Understanding the regulatory mechanisms of phosphorylated Bcl2 is essential for elucidating its role in cancer development and progression, as well as potential therapeutic strategies targeting this pathway. The Phospho-Bcl2 (T56) Polyclonal Antibody provides researchers with a valuable tool for investigating the complex interplay between Bcl2 phosphorylation and apoptotic regulation in cellular processes.
Product Name:
Phospho-Bcl-2-T56 Rabbit Polyclonal Antibody
SKU:
CABP0316
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T56 of human Bcl-2 (NP_000624.2).
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
596
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Human breast carcinoma tissue, using Phospho-Bcl-2-T56 Rabbit pAb (CABP0316).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
