Phospho-ATR-S428 Rabbit Polyclonal Antibody (CABP0676)
- SKU:
- CABP0676
- Product Type:
- Antibody
- Applications:
- WB
- IF
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Phospho-ATR-S428 Rabbit Polyclonal Antibody |
SKU: | CABP0676 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around S428 of human ATR (NP_001175.2). |
Sequence: | DGIS PK |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | FRP1; MEC1; SCKL; FCTCS; SCKL1; Phospho-ATR-S428 |
Positive Sample: | 293T,NIH/3T3,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, PML body. |
Calculated MW: | 301kDa |
Observed MW: | 300kDa |
The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.
Purification Method: | Affinity purification |
Gene ID: | 545 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |