The Phospho-ATF2 (T69/T71) Polyclonal Antibody (CABP0525) is a valuable tool for researchers studying ATF2, a transcription factor that plays a key role in cellular stress response and regulation of gene expression. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It targets the phosphorylated forms of ATF2 at threonine 69 and threonine 71, allowing for precise detection and analysis in a variety of cell types.ATF2 is involved in numerous cellular processes, including cell growth, apoptosis, and response to DNA damage. Phosphorylation at threonine 69 and threonine 71 is known to regulate ATF2 activity and its ability to transcribe target genes involved in these pathways.
This antibody enables researchers to investigate the role of ATF2 phosphorylation in various biological contexts, providing insights into potential therapeutic targets for conditions such as cancer, neurodegenerative diseases, and metabolic disorders.By using the Phospho-ATF2 (T69/T71) Polyclonal Antibody, researchers can uncover new mechanisms underlying ATF2 function and its impact on cellular signaling pathways. This antibody is a valuable tool for advancing our understanding of ATF2-mediated processes and developing novel strategies for the treatment of diseases influenced by ATF2 activity.
Product Name:
Phospho-ATF2-T69/T71 Rabbit Polyclonal Antibody
SKU:
CABP0525
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic phosphorylated peptide around T69 & T71 of human ATF2 (NP_001871.2).
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene
Purification Method:
Affinity purification
Gene ID:
1386
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using Phospho-ATF2-T69/T71 Rabbit pAb (CABP0525) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.Detection: ECL Basic Kit (AbGn00020).
