The Phospho-ARHGAP31 (T789) Antibody (PAC004822) is a valuable tool for researchers studying ARHGAP31, a protein involved in cell signaling and cytoskeletal dynamics. This antibody, raised in rabbits, is highly specific for detecting phosphorylation of ARHGAP31 at threonine 789 in human samples and is validated for use in Western blot applications.ARHGAP31 is a key regulator of Rho GTPases, which play essential roles in cell migration, adhesion, and polarity. Phosphorylation of ARHGAP31 at T789 is known to modulate its activity and affect cellular processes such as cytoskeletal rearrangements and cell motility.
By targeting this specific phosphorylation site, researchers can gain insights into the regulation of ARHGAP31 and its impact on cell behavior.Studies have shown that dysregulation of ARHGAP31 is associated with various diseases, including cancer and neurodevelopmental disorders. The Phospho-ARHGAP31 (T789) Antibody provides a valuable tool for investigating the role of ARHGAP31 phosphorylation in these contexts and may lead to the development of novel therapeutic strategies targeting this pathway.
Antibody Name:
Phospho-ARHGAP31 (T789) Antibody
Antibody SKU:
PACO04822
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from human CdGAP around the phosphorylation site of T789.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ARHGAP31; CDGAP; KIAA1204; Rho GTPase-activating protein 31; Cdc42 GTPase-activating protein
UniProt Protein Function:
CdGAP: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA. Interacts with GTP-loaded RHOU.Protein type: GAPs; GAPs, Rac/RhoChromosomal Location of Human Ortholog: 3q13.33Cellular Component: cytosol; lamellipodiumMolecular Function: GTPase activator activityBiological Process: regulation of small GTPase mediated signal transduction; small GTPase mediated signal transductionDisease: Adams-oliver Syndrome 1
UniProt Protein Details:
NCBI Summary:
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]
