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Description
Product Name: | Phospho-AMPKα1-T183+AMPKα2-T172 Monoclonal Antibody |
SKU: | CABP1441 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic phosphorylated peptide around T183/T172 of human PRKAA1/PRKAA2 (NP_006242.5/NP_006243.2). |
Sequence: | LRTS C |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 |
Synonyms: | AMPKa1/AMPKa2; Phospho-AMPKα1-T183+AMPKα2-T172 |
Positive Sample: | C2C12+HGF(m),C6+AICAR |
Cellular Localization: | Apical plasma membrane, Cytoplasm, Cytosol, Nuclear speck, Nucleoplasm, Nucleus |
Calculated MW: | 64kDa/65kDa/62kDa |
Observed MW: | 62kDa |
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Purification Method: | Affinity purification |
Gene ID: | 5562/5563 |
Clone Number: | ARC62278 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |