Phospho-α-Synuclein-Y136 Rabbit Polyclonal Antibody (CABP0254)
- SKU:
- CABP0254
- Product Type:
- Antibody
- Applications:
- WB
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Product Name: | Phospho-α-Synuclein-Y136 Rabbit Polyclonal Antibody |
| SKU: | CABP0254 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | A synthetic phosphorylated peptide around Y136 of human alpha-Synuclein (NP_000336.1). |
| Sequence: | QDYE P |
| Tested Applications: | WB ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 |
| Synonyms: | PD1; NACP; PARK1; PARK4; Phospho-α-Synuclein-Y136 |
| Positive Sample: | Mouse brain |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, cytosol, synapse. |
| Calculated MW: | 14kDa |
| Observed MW: | 18kDa |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
| Purification Method: | Affinity purification |
| Gene ID: | 6622 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of extracts of Mouse brain, using Phospho-α-Synuclein-Y136 antibody (CABP0254) at 1:1000 dilution.Mouse brain were treated by λ-PP mixed solution (1ul) at 30℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s. |
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