The Phospho-Alpha Synuclein (Y136) Polyclonal Antibody (CABP0254) is a valuable tool for researchers studying the phosphorylation of alpha-synuclein, a protein that plays a crucial role in neurodegenerative disorders such as Parkinson's disease. This antibody, produced in rabbits, is highly specific for detecting phosphorylated alpha-synuclein at the Y136 site in human samples and is validated for use in Western blot applications.Alpha-synuclein is a key player in the pathogenesis of neurodegenerative diseases, with abnormal phosphorylation contributing to the formation of toxic aggregates in the brain.
By targeting the Y136 phosphorylation site, this antibody allows researchers to investigate the role of phosphorylated alpha-synuclein in disease progression and potentially identify novel therapeutic targets.The Phospho-Alpha Synuclein (Y136) Polyclonal Antibody is a valuable tool for advancing our understanding of neurodegenerative disorders and may lead to the development of targeted therapies for these devastating conditions. Its high reactivity and specificity make it a reliable choice for researchers conducting studies in the field of neuroscience and neurology.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
6622
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using Phospho-α-Synuclein-Y136 antibody (CABP0254) at 1:1000 dilution.Mouse brain were treated by λ-PP mixed solution (1ul) at 30℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
