The Phospho-Alpha-Synuclein (Y133) Polyclonal Antibody (CABP0451) is a vital tool for researchers studying alpha-synuclein, a protein linked to neurodegenerative diseases such as Parkinson's and Alzheimer's. This antibody, generated in rabbits, specifically targets the phosphorylated form of alpha-synuclein at tyrosine 133, allowing for precise detection and analysis in various biological samples.Alpha-synuclein is known for its role in the formation of Lewy bodies, abnormal protein aggregates commonly found in the brains of individuals with Parkinson's disease. Phosphorylation at tyrosine 133 has been associated with increased toxicity and aggregation of alpha-synuclein, leading to neuronal dysfunction and cell death.
The CABP0451 antibody enables researchers to investigate the effects of this phosphorylation event on alpha-synuclein function and pathology.By using the Phospho-Alpha-Synuclein (Y133) Polyclonal Antibody, scientists can gain insights into the molecular mechanisms underlying neurodegenerative diseases and potentially identify novel therapeutic targets for intervention. Its high specificity and sensitivity make it a valuable tool for studies in neuroscience, neurology, and drug discovery related to alpha-synuclein-associated disorders.
Product Name:
Phospho-α-Synuclein-Y133 Polyclonal Antibody
SKU:
CABP0451
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A phospho specific peptide corresponding to residues surrounding Y133 of human alpha-Synuclein
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
6622
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using Phospho-α-Synuclein-Y133 pAb (CABP0451) at 1:1000 dilution.Jurkat and NIH/3T3 cells were treated by Pervanadate (1 mM) at 37℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
