The Phospho Alpha-Synuclein (S129) Antibody (CABP0450) is a valuable tool for researchers studying neurodegenerative diseases, particularly Parkinson's disease. This polyclonal antibody, raised in rabbits, specifically targets the phosphorylated form of alpha-synuclein at Serine 129, a key post-translational modification associated with the pathogenesis of Parkinson's disease.Alpha-synuclein is a protein involved in neurotransmitter release and synaptic function, with aberrant aggregation of this protein being a hallmark of Parkinson's disease. Phosphorylation at Serine 129 has been linked to increased toxicity and accumulation of alpha-synuclein aggregates in neurons, leading to neurodegeneration.
Validated for use in Western blot applications, this antibody enables researchers to detect and analyze levels of phospho alpha-synuclein (S129) in various cell types and tissues. By studying the role of this phosphorylation event in the progression of Parkinson's disease, researchers can gain insights into potential therapeutic targets and diagnostic biomarkers for this devastating neurodegenerative disorder.
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
6622
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse brain tissue, using Phospho-α-Synuclein-S129 Rabbit pAb (CABP0450).Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% BSA.
