Phospho-ALOX5-S271 Rabbit Polyclonal Antibody (CABP0573)
- SKU:
- CABP0573
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | Phospho-ALOX5-S271 Rabbit Polyclonal Antibody |
SKU: | CABP0573 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic phosphorylated peptide around S271 of human ALOX5 (NP_000689.1). |
Sequence: | QLSL E |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | 5-LO; 5LPG; LOG5; 5-LOX; Phospho-ALOX5-S271 |
Positive Sample: | HT-29+EGF,HT-29+PMA |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus matrix, Nucleus membrane, Peripheral membrane protein. |
Calculated MW: | 78kDa |
Observed MW: | 78kDa |
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 240 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |